The suggest regular state volume of distribution (Vss) for sildenafil is one zero five L, indicating distribution in to the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both close to ninety six% bound to plasma proteins. Protein binding is unbiased of full drug concentrations.

Dette kan spesielt være dersom tabletten tas med et stort eller fett måltid kan absorberingen av virkemiddelet forsinkes. Alkohol kan redusere effekten av potenspillen, og det anbefales derfor ikke at gentleman tar medisinen i kombinasjon med overdrevne mengder alkohol.

It is not possible to ascertain no matter whether these functions are relevant directly to using PDE5 inhibitors or to other things [see ADVERSE REACTIONS].

There was no impact on sperm motility or morphology after solitary 100 mg oral doses of VIAGRA in healthful volunteers.

Bruk ikke Viagra Reseptfri dersom du er allergisk mot sildenafil eller noen av de andre innholdsstoffene.

Sildenafil er forsåvidt en direkte kopi av Viagra som inneholder den samme mengden virkestoff og fungerer på samme måte som originalen.

It is actually impossible to ascertain regardless of whether these activities are connected directly to using PDE5 inhibitors, on the affected person's fundamental vascular possibility aspects or anatomical defects, to a mix of these variables, or to other elements [see WARNINGS AND Safety measures and Affected person Facts].

Immediately after either oral or intravenous administration, sildenafil is excreted as metabolites predominantly during the feces (close to 80% of administered oral dose) and also to a lesser extent during the urine (approximately 13% with the administered oral read more dose).

Inneholder produkter som ikke kan sendes hjem. Du kan velge Klikk & Hent til ditt foretrukne apotek eller kommisjonær.

Administration of VIAGRA with nitric oxide donors for instance natural and organic nitrates or organic nitrites in any form is contraindicated.

Seksuell aktivitet kan være ekstra belastende for hjertet. Dersom du har hjerteproblemer eller tror du kan ha et hjerteproblem er det viktig at du opplyser om dette i samtalen med farmasøyten i apotek. Du bør ta en helsesjekk hos din fastlege så snart som mulig i løpet av de første 6 månedene etter du har begynt å bruke Viagra Reseptfri.

So, the metabolite is chargeable for about twenty% of sildenafil's action. Sildenafil is excreted as metabolites predominantly during the feces (about 80% of administered oral dose) also to a lesser extent inside the urine (around 13% of the administered oral dose). If taken that has a higher-Fats meal, absorption is diminished; some time taken to reach the utmost plasma concentration will increase by all over one particular hour, and the most concentration itself is diminished by almost just one-3rd.[fifty two]

At 24 hours the plasma amounts of sildenafil had been nevertheless approximately two hundred ng/mL, when compared to roughly 5 ng/mL when sildenafil was dosed by yourself. This is according to ritonavir's marked results on the broad array of P450 substrates. VIAGRA had no impact on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].

Per its regarded outcomes within the nitric oxide/cGMP pathway [see CLINICAL PHARMACOLOGY], VIAGRA was shown to potentiate the hypotensive outcomes of nitrates, and its administration to individuals who will be applying nitric oxide donors which include natural nitrates or natural and organic nitrites in any type possibly often and/or intermittently is therefore contraindicated.